Practically, the reported cases of solitary neurofibroma on the lip are few in the English literatures. Intraorally the various sites of occurrence in the tissue are tongue, intra-osseous of jaw, buccal mucosa, palate and gingival have been reported. Oral neurofibroma is affecting predominantly adults, showing no gender preference or prevalence in females. The rate is estimated to be 25% of all neurofibromas in the head and neck regions and 6.5% in the oral cavity as solitary or multiple lesions associated with NF-1.
The skin is the most frequent location for neurofibromas, but lesions of the oral are not common. As part of the generalized syndrome of neurofibromatosis which is usually neurofibromatosis type 1 (NF-1), also called von Recklinghausen`s disease of the skin. It may occur either as solitary lesions or multiple. It arises from a mixture of cell types, including Schwann cells and peri-neural fibroblasts. Neurofibroma is the most common type of peripheral nerve sheath tumor. MRI: Magnetic resonance imaging, H&E: Hematoxylin-eosin, NF-1: Neurofibromatosis type 1 Introduction Solitary neurofibroma, lip, oral, neurogenic tumors Abbreviations And 4-year follow-up, she was free of symptoms and signs of recurrence were not detected. A diagnosis of solitary neurofibroma was made through a surgical specimen by excisioned intra-orally by general anesthesia, from the lesion by histological examination and immunohistochemistry for the S-100 protein. Due to the suspicion of a tumor in the lip, MRI was taken and hemangioma was considered.
A 69-year-old woman was referred due to a complaint of swelling in the philtrum of upper lip with no other symptoms. But, solitary neurofibroma is particularly a rarity in the Head and Neck. Multiple neurofibromas are seen as part of von Recklinghausen`s neurofibromatosis. Neurofibromas are relatively common benign tumors usually originating from peripheral nerves.